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Gel-filled silica capillaries used to separate fragments for DNA sequencing. The small diameter of the capillaries permit the application of higher electric fields, providing high speed, high throughput separations that are significantly faster than traditional slab gels..
Industry:Biology
Degree of molecular detail on a physical map of DNA, ranging from low to high..
Industry:Biology
Something which causes cancer to occur by causing changes in a cell's DNA.
See also: mutagene.
Industry:Biology
A protein that recognises specific, short nucleotide sequences and cuts DNA at those sites. Bacteria contain over 400 such enzymes that recognise and cut more than 100 different DNA sequences.
See also: restriction enzyme cutting site.
Industry:Biology
Variation between individuals in DNA fragment sizes cut by specific restriction enzymes; polymorphic sequences that result in RFLPs are used as markers on both physical maps and genetic linkage maps. RFLPs usually are caused by mutation at a cutting site.
See also: marker, polymorphism.
Industry:Biology
One crossover event inhibits the chances of another crossover event. Also known as positive interference. Negative interference increases the chance of a second crossover.
See also: crossing over.
Industry:Biology
The basic unit of any living organism that carries on the biochemical processes of life.
See also: genome, nucleus.
Industry:Biology
A specific nucleotide sequence of DNA at which a particular restriction enzyme cuts the DNA. Some sites occur frequently in DNA (e.g., every several hundred base pairs); others much less frequently (rare-cutter; e.g., every 10,000 base pairs)..
Industry:Biology
The period in the cell cycle when DNA is replicated in the nucleus; followed by mitosis..
Industry:Biology
A unit of measure of recombination frequency. One centimorgan is equal to a 1% chance that a marker at one genetic locus will be separated from a marker at a second locus due to crossing over in a single generation. In human beings, one centimorgan is equivalent, on average, to one million base pairs.
See also: megabase.
Industry:Biology
