Anna Nicole is an opera in 2 acts by Mark-Anthony Turnage to an English libretto by Richard Thomas. It received its première on 17 February 2011 at the Royal Opera House, London, directed by Richard Jones. The story is based on the life of Anna Nicole Smith. A recording of the opera was broadcast on BBC Four and BBC iPlayer on 25 March 2011. The broadcast drew in 67,700 viewers. A special introduction and intermission was filmed - hosted by Clemency Burton-Hill. The opera received its European continental premiere at Theater Dortmund (Germany) in April 2013 with American soprano Emily Newton in the title role.

Anna Nicole received its U.S. premiere on September 17, 2013, in a production by the New York City Opera at the Brooklyn Academy of Music. Anna Nicole was the last work to be staged by the City Opera, which ceased operations on October 1, 2013.