Bioinformatics tools aim to exploit the potential of computers to model and understand complex biological systems and phenomena. Initially, the approach used by most bioinformatics tools was more analytical and engineering-like, separating DNA from all other factors and isolating the sequence for a better understanding of the DNA structure. Today, the genomics approach combines various elements, while taking into consideration their relationships as well as evolutionary aspects in space and time. A more global approach is being developed that accounts for biomolecules in their environment, including intra- and intermolecular interactions at the cell, tissue, organ, and organism level.