Every chemical reaction or biochemical pathway is influenced by how molecules interact with each other. Considering this, it is not surprising that isolating ligands with high affinity and specificity for particular receptors is an area of intense research. Ligands for biological receptors could make excellent drug candidates. High-specificity ligands can be used to develop assays for biological, environmental, or industrial analytes of interest. Traditionally, ligands have been discovered using rational molecular design or random combinatorial methods. Both are notoriously labor-intensive processes. SELEX (systematic evolution of ligands through exponential enrichment) provides an alternative approach that uses molecular evolution to isolate high-affinity/selectivity ligands. SELEX can be simplified and shortened by incorporating capillary electrophoresis (CE) selection into the process.