Skeletal muscle is the most voluminous tissue in humans. There are about 670 different muscles in the human body, including 170 distinct skeletal muscles in the head. The skeletal musculature serves crucial functions in vertebrates. The body muscles, including trunk and limb muscles, are responsible for posture and locomotion, whereas the head muscles control the eyes, cranial openings, food uptake (mastication), and speech. Skeletal muscle displays the ability to regenerate after injury or in degenerative diseases. However, this regenerative capacity is exhausted over time and in severe muscle dystrophies.