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primer DNA polymerase

DNA polymerase that provides primers for the DNA polymerization. Unlike RNA polymerase, DNA polymerase is unable to initiate the de novo synthesis of a polynucleotide chain. DNA polymerase can only add nucleotides to a free 3´ hydroxyl group at the end of a pre-existing chain. A short oligonucleotide, known as a primer, is therefore needed to supply such a hydroxyl group for the initiation of DNA synthesis.

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