Rabies is one of the oldest and deadliest zoonotic diseases, killing tens of thousands of people worldwide each year. It is a viral infection typically transmitted to people via bites from infected animals, especially bats and carnivores or domestic mammals. The disease has no cure, but pre- and postexposure prophylaxes are available; therefore, human deaths due to rabies are relatively rare in North America. Because of aggressive vaccination programs for pets, most rabies cases in developed countries such as the United States come from wildlife species, and current rabies management programs are focused on the challenging goal of reducing infection within wildlife (in contrast to reducing infection within domestic species (especially domestic dogs), as is the case in under-developed countries).